Psychopathology: genetics and the stress-vulnerability hypothesis

Creativity and psychopathology: a shared vulnerability model.

Creativity is considered a positive personal trait. However, highly creative people have demonstrated elevated risk for certain forms of psychopathology, including mood disorders, schizophrenia spectrum disorders, and alcoholism. A model of shared vulnerability explains the relation between creativity and psychopathology. This model, supported by recent findings from neuroscience and molecular ...

Stress-Related Psychopathology as a Vulnerability Factor in Drug-Taking: The Role of Sex

Neurobiological Programming of Early Life Stress: Functional Development of Amygdala-Prefrontal Circuitry and Vulnerability for Stress-Related Psychopathology.

Early adverse experiences are associated with heighted vulnerability for stress-related psychopathology across the lifespan. While extensive work has investigated the effects of early adversity on neurobiology in adulthood, developmental approaches can provide further insight on the neurobiological mechanisms that link early experiences and long-term mental health outcomes. In the current revie...

The social brain, stress, and psychopathology.

Social discrimination can have pervasive effects on human health and performance. This notion is a major thread binding together findings in social psychology, health psychology, andepidemiology. From a psychiatric perspective, it mayalsobe critical for amore complete etiological picture of psychopathology. Social influences can be subtle but powerful. For example, priming racial identitycan in...

Psychopathology and pathophysiology of the self in depression - neuropsychiatric hypothesis.

BACKGROUND The question of the self has intrigued philosophers and psychologists for a long time. More recently distinct concepts of self have also been suggested in neuroscience more specifically in neuroimaging. AIMS The aim here is to apply these findings to abnormalities of the self in depression and to develop neuropsychiatric hypothesis. METHODS AND RESULTS Patients with depression su...